In most of his cartoons, Droopy matches wits with either a slick anthropomorphic (the Wolf character "portrays" the crooks in both and its semi-remake, (1946)) or a bulldog named "Spike", sometimes silent, sometimes sporting a accent. Two Droopy cartoons - and - also feature appearances from the curvy heroine of Avery's (1943) as a damsel in distress being pursued by the Wolf. Three later Droopy cartoons - (1953), (1957), and (1958) - feature a slow-moving southern wolf character. Voiced by in a dialect he later used for 's , this wolf was a more deadpan character with a tendency to whistle "" (aka "Jubalio") to himself (much like Huckleberry would sing "" to himself).
Avery took a year-long break from MGM from 1950 to 1951, during which time took over his unit to do one Droopy cartoon, , and several cartoons. Avery returned in late 1951 and continued with Droopy and his one-shots until the Avery unit was dissolved by MGM in 1953. Michael Lah, an Avery animator, stayed on long enough to help and complete after Avery had left the studio. Lah himself then left MGM, but returned in 1955 to direct Droopy cartoons costarring either Spike, now called Butch because of the same-named bulldog in Hanna and Barbera's cartoons, or the "Kingdom Coming"-whistling wolf. One of these, (1957), was nominated for the 1957 for Best Short Subject (Cartoons). However, by the time of s release in December 1957, the MGM cartoon studio had been closed for six months, a casualty of corporate downsizing.
It was speculated that new theatrical shorts were to be produced in 2004, along with newer and cartoons produced by , but owing to the unsuccessful release of in November 2003 which nearly caused the dissolution of the whole studio, production on the planned shorts was canceled. However, unlike some of these and cartoons, no Droopy cartoons were completed. Indeed, it was unknown if these cartoons were produced, probably only a proposed plan if the film was a hit.
On May 15, 2007, (whose corporate sibling now owns the rights to the character) released all of Droopy's MGM cartoons on DVD as .] The seven Droopy cartoons produced in CinemaScope were released in their original widescreen versions, instead of the versions regularly broadcast on television.