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There are grounds for suspicion that sick abdominal fat tissue may produce factors that cause subcutaneous fat tissue to also become “sick” and further contribute to metabolic diseases.
Other potentially detrimental effects of enlarged subcutaneous fat tissue relate to free fatty acids. During fasting, the body can obtain energy through the release of free from the in fat cells. The fatty acids thus become available for release into the blood. If too high a concentration of certain accumulates in the blood because of sick fat tissue, and the body is unable to recruit more healthy fat cells, then existing healthy fat cells become engorged (and thus also sick). The result is that blood fatty acid concentrations increase to levels toxic to tissues such as , , and , and lead to a range of pathological metabolic conditions.
Adiposopathy (or sick fat) refers to certain classes of dysfunction of fat cells. The dysfunctions in question may contribute to many of the adverse metabolic conditions associated with and the associated .